Knockout of Na /Ca exchanger in smooth muscle attenuates vasoconstriction and L-type Ca channel current and lowers blood pressure

Jin Zhang, Chongyu Ren, Ling Chen, Manuel F. Navedo, Laura K. Antos, Stephen P. Kinsey, Takahiro Iwamoto, Kenneth D. Philipson, Michael I. Kotlikoff, Luis F. Santana, W. Gil Wier, Donald R. Matteson,* and Mordecai P. Blaustein* Departments of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Department of Physiology and Biophysics, University of Washington, Seattle, Washington; Department of Pharmacology, Fukuoka University School of Medicine, Fukuoka, Japan; Department of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, California; and Department of Biomedical Sciences, Cornell University Veterinary College, Ithaca, New York